InnateDB Protein
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IDBP-36156.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC17A6
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Protein Name
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solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000263160
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InnateDB Gene
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IDBG-36152 (SLC17A6)
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Protein Structure
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Function |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269PubMed:10820226, ECO:0000269PubMed:11698620}.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. {ECO:0000269PubMed:10820226}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005313
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L-glutamate transmembrane transporter activity
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GO:0015293
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symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
IPR020846
Major facilitator superfamily domain
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P2U8
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PhosphoSite |
PhosphoSite-Q9P2U8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57084
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UniGene |
Hs.242821
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RefSeq |
NP_065079
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HUGO |
HGNC:16703
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OMIM |
607563
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CCDS |
CCDS7856
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HPRD |
10459
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IMGT |
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EMBL |
AB032435
AC040936
BC069629
BC069640
BC069646
CH471064
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GenPept |
AAH69629
AAH69640
AAH69646
BAA92874
EAW68324
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