InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SP1

Summary

InnateDB Protein

IDBP-36618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP1

Protein Name

Sp1 transcription factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329357

InnateDB Gene

IDBG-36616 (SP1)

Protein Structure

UniProt Annotation

Function

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269PubMed:10391891, ECO:0000269PubMed:11371615, ECO:0000269PubMed:11904305, ECO:0000269PubMed:14593115, ECO:0000269PubMed:16377629, ECO:0000269PubMed:16478997, ECO:0000269PubMed:16943418, ECO:0000269PubMed:17049555, ECO:0000269PubMed:18171990, ECO:0000269PubMed:18199680, ECO:0000269PubMed:18239466, ECO:0000269PubMed:18513490, ECO:0000269PubMed:18619531, ECO:0000269PubMed:19193796, ECO:0000269PubMed:20091743, ECO:0000269PubMed:21798247}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

Disease Associations

Tissue Specificity

Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. {ECO:0000269PubMed:21798247}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	362 [view]
Protein-Protein	304 [view]
Protein-DNA	53 [view]
Protein-RNA	1 [view]
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0035326	enhancer binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0071837	HMG box domain binding

Biological Process

GO:0001503	ossification
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0030219	megakaryocyte differentiation
GO:0030324	lung development
GO:0043353	enucleate erythrocyte differentiation
GO:0043923	positive regulation by host of viral transcription
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060216	definitive hemopoiesis