Version 5.4
Homo sapiens Protein: SP1
Summary
InnateDB Protein IDBP-376277.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SP1
Protein Name Sp1 transcription factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000404263
InnateDB Gene IDBG-36616 (SP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 362 [view]
Protein-Protein 304 [view]
Protein-DNA 53 [view]
Protein-RNA 1 [view]
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0071837 HMG box domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0043923 positive regulation by host of viral transcription
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08047
PhosphoSite PhosphoSite-P08047
TrEMBL H3BVI2
UniProt Splice Variant
Entrez Gene 6667
UniGene Hs.649191
RefSeq NP_003100
HUGO HGNC:11205
OMIM 189906
CCDS CCDS44898
HPRD 01796
IMGT
EMBL AB039286 AC068889 AC073611 AF252284 AF255682 AJ272134 BC043224 BC062539 CH471054 FJ949572 FN908228 J03133
GenPept AAA61154 AAF67726 AAF78781 AAH43224 AAH62539 ACR22508 BAB13476 CAB75345 CBM42955 EAW96699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca