InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn1a

Summary

InnateDB Protein

IDBP-401292.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn1a

Protein Name

cyclin-dependent kinase inhibitor 1A (P21)

Synonyms

CAP20; CDKI; Cdkn1; CIP1; mda6; P21; p21Cip1; p21WAF; SDI1; Waf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113150

InnateDB Gene

IDBG-159848 (Cdkn1a)

Protein Structure

UniProt Annotation

Function

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:20154723}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 241 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	32 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	241 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019912	cyclin-dependent protein kinase activating kinase activity
GO:0030332	cyclin binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050	cell cycle arrest
GO:0007265	Ras protein signal transduction
GO:0007346	regulation of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0009411	response to UV
GO:0009636	response to toxic substance
GO:0010243	response to organonitrogen compound
GO:0010332	response to gamma radiation
GO:0010629	negative regulation of gene expression
GO:0030308	negative regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0031100	organ regeneration
GO:0031668	cellular response to extracellular stimulus
GO:0033158	regulation of protein import into nucleus, translocation
GO:0042493	response to drug
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066	negative regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0046685	response to arsenic-containing substance
GO:0048146	positive regulation of fibroblast proliferation
GO:0051412	response to corticosterone
GO:0051726	regulation of cell cycle
GO:0055093	response to hyperoxia
GO:0071479	cellular response to ionizing radiation
GO:0071850	mitotic cell cycle arrest
GO:0090398	cellular senescence
GO:2000278	regulation of DNA biosynthetic process
GO:2000379	positive regulation of reactive oxygen species metabolic process