InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IRAK3

Summary

InnateDB Protein

IDBP-45586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRAK3

Protein Name

interleukin-1 receptor-associated kinase 3

Synonyms

ASRT5; IRAKM;

Species

Homo sapiens

Ensembl Protein

ENSP00000261233

InnateDB Gene

IDBG-45584 (IRAK3)

Protein Structure

UniProt Annotation

Function

Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. {ECO:0000250UniProtKB:Q8K4B2}.

Subcellular Localization

Disease Associations

Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269PubMed:17503328}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed predominantly in peripheral blood lymphocytes. {ECO:0000269PubMed:10383454}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0010933	positive regulation of macrophage tolerance induction
GO:0010936	negative regulation of macrophage cytokine production
GO:0019221	cytokine-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042177	negative regulation of protein catabolic process
GO:0043242	negative regulation of protein complex disassembly
GO:0043244	regulation of protein complex disassembly
GO:0043330	response to exogenous dsRNA
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00531
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00005
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt