InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP2CA

Summary

InnateDB Protein

IDBP-482184.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2CA

Protein Name

protein phosphatase 2, catalytic subunit, alpha isozyme

Synonyms

PP2Ac; PP2CA; PP2Calpha; RP-C;

Species

Homo sapiens

Ensembl Protein

ENSP00000418447

InnateDB Gene

IDBG-44693 (PPP2CA)

Protein Structure

UniProt Annotation

Function

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. {ECO:0000250, ECO:0000269PubMed:10801873, ECO:0000269PubMed:22613722, ECO:0000269PubMed:9920888}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16541025}. Nucleus {ECO:0000269PubMed:16541025}. Chromosome, centromere {ECO:0000269PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 301 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	301 [view]
Protein-Protein	296 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity
GO:0050811	GABA receptor binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188	inactivation of MAPK activity
GO:0000278	mitotic cell cycle
GO:0001932	regulation of protein phosphorylation
GO:0006275	regulation of DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0006672	ceramide metabolic process
GO:0006915	apoptotic process
GO:0007084	mitotic nuclear envelope reassembly
GO:0007126	meiotic nuclear division
GO:0007498	mesoderm development
GO:0008380	RNA splicing
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010033	response to organic substance
GO:0010467	gene expression
GO:0010469	regulation of receptor activity
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019932	second-messenger-mediated signaling
GO:0030111	regulation of Wnt signaling pathway
GO:0030155	regulation of cell adhesion
GO:0030308	negative regulation of cell growth
GO:0031952	regulation of protein autophosphorylation
GO:0040008	regulation of growth
GO:0042176	regulation of protein catabolic process
GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595	regulation of cell differentiation
GO:0070208	protein heterotrimerization
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt