InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD80

Summary

InnateDB Protein

IDBP-51289.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD80

Protein Name

CD80 molecule

Synonyms

B7; B7-1; B7.1; BB1; CD28LG; CD28LG1; LAB7;

Species

Homo sapiens

Ensembl Protein

ENSP00000264246

InnateDB Gene

IDBG-51287 (CD80)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269PubMed:10583602}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed on activated B-cells, macrophages and dendritic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0016032	viral process
GO:0031295	T cell costimulation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042110	T cell activation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF08205

PRINTS

PIRSF

SMART

SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33681