InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx58

Summary

InnateDB Protein

IDBP-536590.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx58

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115052

InnateDB Gene

IDBG-135957 (Ddx58)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	11 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity

Biological Process

GO:0008152	metabolic process
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)

Cellular Component

Protein Structure and Domains

PDB ID

MGI:2442858

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite