Version 5.4
Mus musculus Protein: Nlrp3
Summary
InnateDB Protein IDBP-540533.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nlrp3
Protein Name NLR family, pyrin domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000114231
InnateDB Gene IDBG-178924 (Nlrp3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002674 negative regulation of acute inflammatory response
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032611 interleukin-1 beta production
GO:0032621 interleukin-18 production
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0044546 NLRP3 inflammasome complex assembly
GO:0045087 innate immune response (InnateDB)
GO:0050701 interleukin-1 secretion
GO:0050713 negative regulation of interleukin-1 beta secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0072559 NLRP3 inflammasome complex
Protein Structure and Domains
PDB ID MGI:2653833
InterPro IPR004020 DAPIN domain
IPR011029 Death-like domain
PFAM PF02758
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5SXI6
UniProt Splice Variant
Entrez Gene 216799
UniGene Mm.54174
RefSeq
MGI ID
MGI Symbol Nlrp3
OMIM
CCDS
HPRD
IMGT
EMBL AL592522
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca