InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GYS1

Summary

InnateDB Protein

IDBP-61645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GYS1

Protein Name

glycogen synthase 1 (muscle)

Synonyms

GSY; GYS;

Species

Homo sapiens

Ensembl Protein

ENSP00000317904

InnateDB Gene

IDBG-61643 (GYS1)

Protein Structure

UniProt Annotation

Function

Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.

Subcellular Localization

Disease Associations

Muscle glycogen storage disease 0 (GSD0b) [MIM:611556]: Metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work. {ECO:0000269PubMed:17928598}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004373	glycogen (starch) synthase activity
GO:0005515	protein binding
GO:0005536	glucose binding
GO:0019901	protein kinase binding
GO:0061547	glycogen synthase activity, transferring glucose-1-phosphate

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006006	glucose metabolic process
GO:0007507	heart development
GO:0009058	biosynthetic process
GO:0044281	small molecule metabolic process