InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sp1

Summary

InnateDB Protein

IDBP-625971.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sp1

Protein Name

trans-acting transcription factor 1

Synonyms

1110003E12Rik; AA450830; AI845540; Sp1-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130747

InnateDB Gene

IDBG-188607 (Sp1)

Protein Structure

UniProt Annotation

Function

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000250, ECO:0000269PubMed:24030830}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 256 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	41 [view]
Protein-DNA	19 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	256 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035326	enhancer binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030219	megakaryocyte differentiation
GO:0030324	lung development
GO:0043353	enucleate erythrocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:98372

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O89090

PhosphoSite

PhosphoSite-O89090

TrEMBL

UniProt Splice Variant

Entrez Gene

20683

UniGene

Mm.4618

RefSeq

MGI ID

MGI Symbol

Sp1

OMIM

CCDS

HPRD

IMGT

EMBL

AF022363 AF062566 S79832 X60136

GenPept

AAB35321 AAC08527 AAC16484 CAA42721