Version 5.4
Mus musculus Protein: Sp1
Summary
InnateDB Protein IDBP-625974.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sp1
Protein Name trans-acting transcription factor 1
Synonyms 1110003E12Rik; AA450830; AI845540; Sp1-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000127445
InnateDB Gene IDBG-188607 (Sp1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 256 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 41 [view]
Protein-DNA 19 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 256 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0035326 enhancer binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0071837 HMG box domain binding
Biological Process
GO:0001503 ossification
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0006355 regulation of transcription, DNA-templated
GO:0030219 megakaryocyte differentiation
GO:0030324 lung development
GO:0043353 enucleate erythrocyte differentiation
GO:0043923 positive regulation by host of viral transcription
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048706 embryonic skeletal system development
GO:0060136 embryonic process involved in female pregnancy
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0005634 nucleus
GO:0032993 protein-DNA complex
Protein Structure and Domains
PDB ID MGI:98372
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q2V3
UniProt Splice Variant
Entrez Gene 20683
UniGene Mm.4618
RefSeq
MGI ID
MGI Symbol Sp1
OMIM
CCDS
HPRD
IMGT
EMBL AC137156
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca