Version 5.4
Bos taurus Protein: TLR2
Summary
InnateDB Protein IDBP-680423.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLR2
Protein Name toll-like receptor 2 precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010530
InnateDB Gene IDBG-629032 (TLR2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0008329 signaling pattern recognition receptor activity
GO:0042497 triacyl lipopeptide binding
GO:0042498 diacyl lipopeptide binding
GO:0042834 peptidoglycan binding
GO:0046982 protein heterodimerization activity
GO:0070891 lipoteichoic acid binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002238 response to molecule of fungal origin
GO:0002376 immune system process
GO:0002687 positive regulation of leukocyte migration
GO:0002752 cell surface pattern recognition receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007252 I-kappaB phosphorylation
GO:0009617 response to bacterium
GO:0030177 positive regulation of Wnt signaling pathway
GO:0032494 response to peptidoglycan
GO:0032695 negative regulation of interleukin-12 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042495 detection of triacyl bacterial lipopeptide
GO:0042496 detection of diacyl bacterial lipopeptide
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0042892 chloramphenicol transport
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050707 regulation of cytokine secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050729 positive regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0052063 induction by symbiont of defense-related host nitric oxide production
GO:0060907 positive regulation of macrophage cytokine production
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0071727 cellular response to triacyl bacterial lipopeptide
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR017241 Toll-like receptor
PFAM PF01582
PF13676
PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF PIRSF037595
SMART SM00255
SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q56GY8
UniProt Splice Variant
Entrez Gene 281534
UniGene Bt.8945
RefSeq NP_776622
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY957623 DAAA02044145 EU546167
GenPept AAX56980 ACB38267

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca