Bos taurus Protein: EEF1A1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-680990.2 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | EEF1A1 | ||||||||||||
Protein Name | Elongation factor 1-alpha 1 | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Protein | ENSBTAP00000019318 | ||||||||||||
InnateDB Gene | IDBG-629576 (EEF1A1) | ||||||||||||
Protein Structure |
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UniProt Annotation | |||||||||||||
Function | This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens (By similarity). {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 245 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR004160 Translation elongation factor EFTu/EF1A, C-terminal IPR004161 Translation elongation factor EFTu/EF1A, domain 2 IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal IPR009000 Translation protein, beta-barrel domain IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00009
PF03143 PF03144 |
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PRINTS |
PR00315
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PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | P68103 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | Q862L7 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 282220 | ||||||||||||
UniGene | Bt.90870 | ||||||||||||
RefSeq | |||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AB060107 AB098965 AB098991 AB099079 AF013213 AJ238405 BC105315 BC142302 DQ347565 | ||||||||||||
GenPept | AAB65435 AAI05316 AAI42303 ABC55274 BAB60846 BAC56455 BAC56481 BAC56569 CAB88863 | ||||||||||||