InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DDX58

Summary

InnateDB Protein

IDBP-681256.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX58

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053514

InnateDB Gene

IDBG-629773 (DDX58)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0042802	identical protein binding

Biological Process

GO:0002230	positive regulation of defense response to virus by host
GO:0008152	metabolic process
GO:0009597	detection of virus
GO:0009615	response to virus
GO:0030334	regulation of cell migration
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0039529	RIG-I signaling pathway
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005737	cytoplasm
GO:0005923	tight junction
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021673 C-terminal domain of RIG-I
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270
PF11648

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite