InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CDKN1A

Summary

InnateDB Protein

IDBP-681594.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN1A

Protein Name

cyclin-dependent kinase inhibitor 1

Synonyms

CIP1; p21; SDI1; WAF1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011001

InnateDB Gene

IDBG-630156 (CDKN1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 227 interaction(s) predicted by orthology.

Predicted by orthology
Total	227 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019912	cyclin-dependent protein kinase activating kinase activity
GO:0030332	cyclin binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050	cell cycle arrest
GO:0007265	Ras protein signal transduction
GO:0007346	regulation of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0009411	response to UV
GO:0010629	negative regulation of gene expression
GO:0030308	negative regulation of cell growth
GO:0030890	positive regulation of B cell proliferation
GO:0031668	cellular response to extracellular stimulus
GO:0033158	regulation of protein import into nucleus, translocation
GO:0042326	negative regulation of phosphorylation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043068	positive regulation of programmed cell death
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0048146	positive regulation of fibroblast proliferation
GO:0051726	regulation of cell cycle
GO:0071479	cellular response to ionizing radiation
GO:0071850	mitotic cell cycle arrest
GO:0090398	cellular senescence
GO:2000278	regulation of DNA biosynthetic process
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle
GO:0070557	PCNA-p21 complex

Protein Structure and Domains

PDB ID

InterPro

IPR003175 Cyclin-dependent kinase inhibitor

PFAM

PF02234

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A5PKM2

UniProt Splice Variant

Entrez Gene

513497

UniGene

Bt.2749

RefSeq

NP_001092428

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC142538 DAAA02054985

GenPept

AAI42539