Version 5.4
Bos taurus Protein: ERAL1
Summary
InnateDB Protein IDBP-683724.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERAL1
Protein Name GTPase Era, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020770
InnateDB Gene IDBG-632131 (ERAL1)
Protein Structure
UniProt Annotation
Function Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes on the matrix side on the mitochondrial inner membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0015093 ferrous iron transmembrane transporter activity
GO:0019843 rRNA binding
GO:0043024 ribosomal small subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0007264 small GTPase mediated signal transduction
GO:0015684 ferrous iron transport
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000795 Elongation factor, GTP-binding domain
IPR001401 Dynamin, GTPase domain
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR006703 AIG1
IPR009019 K homology domain, prokaryotic type
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00009
PF00350
PF01926
PF04548
PF02421
PF08477
PRINTS PR00315
PR00326
PIRSF
SMART SM00053
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5PK43
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 523344
UniGene Bt.12454
RefSeq NP_001092492
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142348
GenPept AAI42349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca