InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NOD1

Summary

InnateDB Protein

IDBP-685170.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOD1

Protein Name

nucleotide-binding oligomerization domain containing 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053171

InnateDB Gene

IDBG-633439 (NOD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0050700	CARD domain binding

Biological Process

GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0016045	detection of bacterium
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0035556	intracellular signal transduction
GO:0042228	interleukin-8 biosynthetic process
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0050830	defense response to Gram-positive bacterium
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001315 CARD domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619

PRINTS

PIRSF

SMART

SM00114
SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite