InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PPP2CA

Summary

InnateDB Protein

IDBP-698549.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP2CA

Protein Name

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000596

InnateDB Gene

IDBG-645797 (PPP2CA)

Protein Structure

UniProt Annotation

Function

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 194 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	194 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050811	GABA receptor binding

Biological Process

GO:0007126	meiotic nuclear division
GO:0007498	mesoderm development
GO:0008152	metabolic process
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016311	dephosphorylation
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0000775	chromosome, centromeric region
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00149

PRINTS

PR00114

PIRSF

SMART

SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P67774

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282320

UniGene

Bt.34380

RefSeq

NP_851374

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC147979 M16968 X52554 X72858

GenPept

AAA30695 AAI47980 CAA36789 CAA51381