InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFTUD2

Summary

InnateDB Protein

IDBP-758802.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFTUD2

Protein Name

Synonyms

MFDGA; MFDM; SNRNP116; Snrp116; Snu114; U5-116KD;

Species

Homo sapiens

Ensembl Protein

ENSP00000465058

InnateDB Gene

IDBG-54412 (EFTUD2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	147 [view]
Protein-Protein	144 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006184	GTP catabolic process
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005517 Translation elongation factor EFG/EF2, domain IV
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF03144
PF03764
PF14492

PRINTS

PR00315

PIRSF

SMART

SM00838
SM00889

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt