Version 5.4
Homo sapiens Protein: E2F1
Summary
InnateDB Protein IDBP-809444.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F1
Protein Name E2F transcription factor 1
Synonyms E2F-1; RBAP1; RBBP3; RBP3;
Species Homo sapiens
Ensembl Protein ENSP00000480001
InnateDB Gene IDBG-67214 (E2F1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 599 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 601 [view]
Protein-Protein 176 [view]
Protein-DNA 422 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000080 mitotic G1 phase
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000085 mitotic G2 phase
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628 positive regulation of gene expression
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048255 mRNA stabilization
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0035189 Rb-E2F complex
Protein Structure and Domains
PDB ID
InterPro IPR003316 Transcription factor E2F/dimerisation partner (TDP)
PFAM PF02319
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1869
UniGene
RefSeq
HUGO HGNC:3113
OMIM 189971
CCDS
HPRD
IMGT
EMBL AF516106 AL121906 BC050369 BC058902 M96577 S49592 S74230 U47675 U47676 U47677
GenPept AAA35782 AAB24289 AAC50719 AAD14150 AAH50369 AAH58902 AAM47604 CAC08486

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca