InnateDB Protein
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IDBP-82611.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGFG1
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Protein Name
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ArfGAP with FG repeats 1
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Synonyms
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HRB; RAB; RIP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362775
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InnateDB Gene
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IDBG-82607 (AGFG1)
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Protein Structure
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Function |
Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269PubMed:10613896, ECO:0000269PubMed:14701878, ECO:0000269PubMed:15749819}.
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Subcellular Localization |
Nucleus. Cytoplasmic vesicle.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:7634337}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
|
Protein-Protein |
32
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001164
Arf GTPase activating protein
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PFAM |
PF01412
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PRINTS |
PR00405
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PIRSF |
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SMART |
SM00105
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TIGRFAMs |
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Modification |
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SwissProt |
P52594
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PhosphoSite |
PhosphoSite-P52594
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3267
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UniGene |
Hs.707245
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RefSeq |
NP_001128661
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HUGO |
HGNC:5175
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OMIM |
600862
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CCDS |
CCDS46535
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HPRD |
02918
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IMGT |
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EMBL |
AC097662
AC105286
AK097451
BC030592
BC096272
BC096273
BC096274
BC096275
L42025
X89478
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GenPept |
AAC37580
AAH30592
AAH96272
AAH96273
AAH96274
AAH96275
AAX93270
AAY24254
BAG53473
CAA61667
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