InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGFG1

Summary

InnateDB Protein

IDBP-82611.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGFG1

Protein Name

ArfGAP with FG repeats 1

Synonyms

HRB; RAB; RIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000362775

InnateDB Gene

IDBG-82607 (AGFG1)

Protein Structure

UniProt Annotation

Function

Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. {ECO:0000250, ECO:0000269PubMed:10613896, ECO:0000269PubMed:14701878, ECO:0000269PubMed:15749819}.

Subcellular Localization

Nucleus. Cytoplasmic vesicle.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:7634337}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0006406	mRNA export from nucleus
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity