InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: E2f1

Summary

InnateDB Protein

IDBP-210418.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2f1

Protein Name

E2F transcription factor 1

Synonyms

E2F-1; mKIAA4009;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099434

InnateDB Gene

IDBG-210416 (E2f1)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. {ECO:0000269PubMed:9674698}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 149 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	25 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	149 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628	positive regulation of gene expression
GO:0030900	forebrain development
GO:0043276	anoikis
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048255	mRNA stabilization
GO:0051726	regulation of cell cycle
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990086	lens fiber cell apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle