InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nod1

Summary

InnateDB Protein

IDBP-619694.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nod1

Protein Name

nucleotide-binding oligomerization domain containing 1

Synonyms

C230079P11; Card4; F830007N14Rik; Nlrc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130487

InnateDB Gene

IDBG-149298 (Nod1)

Protein Structure

UniProt Annotation

Function

Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Apical cell membrane {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042803	protein homodimerization activity
GO:0050700	CARD domain binding

Biological Process

GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952	defense response
GO:0016045	detection of bacterium
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0035556	intracellular signal transduction
GO:0042228	interleukin-8 biosynthetic process
GO:0042742	defense response to bacterium
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0050830	defense response to Gram-positive bacterium
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:1341839

InterPro

IPR001315 CARD domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619

PRINTS

PIRSF

SMART

SM00114
SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BHB0