InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IRAKM

Summary

InnateDB Protein

IDBP-686082.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IRAKM

Protein Name

Interleukin-1 receptor-associated kinase M transcript variant 1Interleukin-1 receptor-associated kinase M transcript variant 2

Synonyms

IrakM;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000033611

InnateDB Gene

IDBG-634310 (IRAKM)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006468	protein phosphorylation
GO:0010933	positive regulation of macrophage tolerance induction
GO:0010936	negative regulation of macrophage cytokine production
GO:0016310	phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032695	negative regulation of interleukin-12 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042177	negative regulation of protein catabolic process
GO:0043242	negative regulation of protein complex disassembly
GO:0043244	regulation of protein complex disassembly
GO:0043330	response to exogenous dsRNA
GO:0043407	negative regulation of MAP kinase activity
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070498	interleukin-1-mediated signaling pathway
GO:0070555	response to interleukin-1

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B3FXL5

UniProt Splice Variant

Entrez Gene

510342

UniGene

Bt.31286

RefSeq

NP_001177228

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02013312 DAAA02013313 DAAA02013314 EU528624

GenPept

ACD50137