Version 5.4
Homo sapiens Gene: SEMA4A
Summary
InnateDB Gene IDBG-103399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA4A
Gene Name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196189
Encoded Proteins
IDBP-103401
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-103403
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-103405
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-103407
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-103411
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-389047
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-389050
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
IDBP-389053
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:156147366-156177752
Strand Forward strand
Band q22
Transcripts
ENST00000355014 ENSP00000347117
ENST00000368286 ENSP00000357269
ENST00000368285 ENSP00000357268
ENST00000368284 ENSP00000357267
ENST00000368282 ENSP00000357265
ENST00000435124 ENSP00000401391
ENST00000414683 ENSP00000399230
ENST00000438830 ENSP00000392865
ENST00000485575
ENST00000470306
ENST00000487358
ENST00000466698
ENST00000469065
ENST00000462892
ENST00000484155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0002292 T cell differentiation involved in immune response
GO:0007275 multicellular organismal development
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0010594 regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0045063 T-helper 1 cell differentiation
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028064
View Gene Order
ENSBTAG00000012228
Not yet available
Pathways
NETPATH
REACTOME
REACT_19200
Other semaphorin interactions pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
plexind1_pathway
Plexin-D1 Signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.408846
RefSeq NM_001193300 NM_001193301 NM_001193302 NM_022367
HUGO
OMIM
CCDS CCDS1132 CCDS53378
HPRD 09528
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca