Allergy and Asthma Curated Interactions

As a proof-of-principle of the value of annotating the "allergy interactome" (i.e. the collection of molecular interactions of relevance to allergy), the InnateDB team was funded in 2011 by AllerGen (strategic project grant) to establish a small curation team over several weeks to interrogate the literature for molecular interactions of relevance to allergy/asthma. After a general review of databases, their pathway coverage, and AllerGen priorities, the curation team focused on molecular interactions involving component molecules of the KEGG Asthma Pathway and a number of genes implicated in genome-wide associations of asthma. Over this period the team annotated 6754 human, mouse and rat molecular interactions of relevance to allergy/asthma that are published in the biomedical literature but were not previously annotated in either InnateDB or any of the top 5 other public molecular interaction databases.

The current version includes a subset of 6754 manually curated interactions involving 800 human or mouse genes. An extra 139 interactions were shown in species currently not part of InnateDB.

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