InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SP1

Summary

InnateDB Gene

IDBG-36616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SP1

Gene Name

Sp1 transcription factor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000185591

Encoded Proteins

IDBP-36618

Sp1 transcription factor

IDBP-376277

Sp1 transcription factor

IDBP-718048

IDBP-717659

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:53380176-53416446

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000327443	ENSP00000329357
ENST00000426431	ENSP00000404263
ENST00000551969	ENSP00000457804
ENST00000548560	ENSP00000458133

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 357 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	362 [view]
Protein-Protein	304 [view]
Protein-DNA	53 [view]
Protein-RNA	1 [view]
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0035326	enhancer binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0071837	HMG box domain binding

Biological Process

GO:0001503	ossification
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0010467	gene expression
GO:0016032	viral process
GO:0030219	megakaryocyte differentiation
GO:0030324	lung development
GO:0043353	enucleate erythrocyte differentiation
GO:0043923	positive regulation by host of viral transcription
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060136	embryonic process involved in female pregnancy
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0032993	protein-DNA complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001280

View Gene Order

ENSBTAG00000003021

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_4

EGFR1 pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_22

Leptin pathway

REACTOME

REACT_120734

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway

REACT_116145

PPARA activates gene expression pathway

REACT_19241

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway

REACT_147904

Activation of gene expression by SREBF (SREBP) pathway

REACT_147797

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_120956

Cellular responses to stress pathway

REACT_169107

SMAD4 MH2 Domain Mutants in Cancer pathway

REACT_169325

Oncogene Induced Senescence pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_169219

Loss of Function of SMAD4 in Cancer pathway

REACT_169398

Loss of Function of SMAD2/3 in Cancer pathway

REACT_169122

Signaling by TGF-beta Receptor Complex in Cancer pathway

REACT_169192

TGFBR2 MSI Frameshift Mutants in Cancer pathway

REACT_111102

Signal Transduction pathway

REACT_121061

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway

REACT_169165

SMAD2/3 MH2 Domain Mutants in Cancer pathway

REACT_169435

Loss of Function of TGFBR2 in Cancer pathway

REACT_169103

SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway

REACT_169274

Cellular Senescence pathway

REACT_169263

TGFBR1 KD Mutants in Cancer pathway

REACT_169311

Loss of Function of TGFBR1 in Cancer pathway

REACT_169445

TGFBR1 LBD Mutants in Cancer pathway

REACT_111217

Metabolism pathway

REACT_169440

TGFBR2 Kinase Domain Mutants in Cancer pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_6844

Signaling by TGF-beta Receptor Complex pathway

KEGG

hsa04350

TGF-beta signaling pathway pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

p53downstreampathway

Direct p53 effectors

myc_represspathway

Validated targets of C-MYC transcriptional repression

ap1_pathway

AP-1 transcription factor network

hif2pathway

HIF-2-alpha transcription factor network

p73pathway

p73 transcription factor network

cmyb_pathway

C-MYB transcription factor network

e2f_pathway

E2F transcription factor network

il4_2pathway

IL4-mediated signaling events

smad2_3nuclearpathway

Regulation of nuclear SMAD2/3 signaling

hif1_tfpathway

HIF-1-alpha transcription factor network

il2_stat5pathway

IL2 signaling events mediated by STAT5

tap63pathway

Validated transcriptional targets of TAp63 isoforms

foxm1pathway

FOXM1 transcription factor network

hnf3apathway

FOXA1 transcription factor network

telomerasepathway

Regulation of Telomerase

Cross-References

SwissProt

P08047

TrEMBL

C4PGM0 H3BVI2

UniProt Splice Variant

Entrez Gene

6667

UniGene

Hs.614020 Hs.620754 Hs.625559 Hs.649191

RefSeq

NM_003109 XM_006719570 XM_006719571 NM_001251825 NM_138473

HUGO

HGNC:11205

OMIM

189906

CCDS

CCDS44898 CCDS8857

HPRD

01796

IMGT

EMBL

AB039286 AC068889 AC073611 AF252284 AF255682 AJ272134 BC043224 BC062539 CH471054 FJ949572 FN908228 J03133

GenPept

AAA61154 AAF67726 AAF78781 AAH43224 AAH62539 ACR22508 BAB13476 CAB75345 CBM42955 EAW96699

RNA Seq Atlas

6667