InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSNK2A1

Summary

InnateDB Gene

IDBG-37787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK2A1

Gene Name

casein kinase 2, alpha 1 polypeptide

Synonyms

CK2A1; CKII; CSNK2A3

Species

Homo sapiens

Ensembl Gene

ENSG00000101266

Encoded Proteins

IDBP-37789

casein kinase 2, alpha 1 polypeptide

IDBP-37793

casein kinase 2, alpha 1 polypeptide

IDBP-228734

casein kinase 2, alpha 1 polypeptide

IDBP-228736

casein kinase 2, alpha 1 polypeptide

IDBP-808098

casein kinase 2, alpha 1 polypeptide

IDBP-808048

casein kinase 2, alpha 1 polypeptide

IDBP-808100

casein kinase 2, alpha 1 polypeptide

IDBP-808101

casein kinase 2, alpha 1 polypeptide

IDBP-808104

casein kinase 2, alpha 1 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012] Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:473591-543821

Strand

Reverse strand

Band

p13

Transcripts

ENST00000217244	ENSP00000217244
ENST00000349736	ENSP00000339247
ENST00000400227	ENSP00000383086
ENST00000400217	ENSP00000383076
ENST00000460062	ENSP00000477147
ENST00000619801	ENSP00000481572
ENST00000609606
ENST00000608066	ENSP00000476486
ENST00000609525	ENSP00000476547
ENST00000608490
ENST00000619188	ENSP00000479630

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 440 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	440 [view]
Protein-Protein	433 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0047485	protein N-terminus binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030307	positive regulation of cell growth
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732	positive regulation of protein catabolic process
GO:0048511	rhythmic process
GO:0061077	chaperone-mediated protein folding
GO:0071174	mitotic spindle checkpoint