InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: E2F1

Summary

InnateDB Gene

IDBG-67214.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F1

Gene Name

E2F transcription factor 1

Synonyms

E2F-1; RBAP1; RBBP3; RBP3

Species

Homo sapiens

Ensembl Gene

ENSG00000101412

Encoded Proteins

IDBP-67218

E2F transcription factor 1

IDBP-809444

E2F transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21131441

E2F1 is important for normal inflammatory response to systemic LPS by enhancing the production of IL6 and TNFA in macrophages. (Demonstrated in murine model)

PMID 22310660

E2F1 directly binds to the promoter of TLR3 to inhibit transcription. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21131441

[Mus musculus] E2f1 is important for normal inflammatory response to systemic LPS by enhancing the production of Il6 and Tnfa in murine macrophages.

PMID 22310660

[Mus musculus] E2f1 directly binds to the promoter of Tlr3 to inhibit transcription.

Entrez Gene

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:33675487-33686404

Strand

Reverse strand

Band

q11.22

Transcripts

ENST00000343380	ENSP00000345571
ENST00000622594	ENSP00000480001

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 599 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	601 [view]
Protein-Protein	176 [view]
Protein-DNA	422 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000080	mitotic G1 phase
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000085	mitotic G2 phase
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007219	Notch signaling pathway
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628	positive regulation of gene expression
GO:0030900	forebrain development
GO:0043276	anoikis
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048255	mRNA stabilization
GO:0051726	regulation of cell cycle
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1990086	lens fiber cell apoptotic process
GO:2000045	regulation of G1/S transition of mitotic cell cycle