Version 5.4
Homo sapiens Gene: JUN
Summary
InnateDB Gene IDBG-99221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JUN
Gene Name jun proto-oncogene
Synonyms AP-1; AP1; c-Jun
Species Homo sapiens
Ensembl Gene ENSG00000177606
Encoded Proteins
IDBP-99223
jun proto-oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20557936
JUN interacts with NFATC2 to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
Entrez Gene
Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:58780788-58784327
Strand Reverse strand
Band p32.1
Transcripts
ENST00000371222 ENSP00000360266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 519 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 521 [view]
Protein-Protein 288 [view]
Protein-DNA 227 [view]
Protein-RNA 1 [view]
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0035497 cAMP response element binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0044822 poly(A) RNA binding
GO:0070412 R-SMAD binding
GO:0071837 HMG box domain binding
Biological Process
GO:0001525 angiogenesis
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003151 outflow tract morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007184 SMAD protein import into nucleus
GO:0007568 aging
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0009987 cellular process
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0030224 monocyte differentiation
GO:0031103 axon regeneration
GO:0031953 negative regulation of protein autophosphorylation
GO:0032321 positive regulation of Rho GTPase activity
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035026 leading edge cell differentiation
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0045087 innate immune response (InnateDB)
GO:0045657 positive regulation of monocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051365 cellular response to potassium ion starvation
GO:0051403 stress-activated MAPK cascade
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0051899 membrane depolarization
GO:0060395 SMAD protein signal transduction
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0000228 nuclear chromosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005829 cytosol
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052684
View Gene Order
ENSBTAG00000004037
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_21326
Activation of the AP-1 family of transcription factors pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_120956
Cellular responses to stress pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_299
Signaling by NOTCH pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
EGF signaling pathway pathway
INOH website
TNFR1 signaling pathway pathway
INOH website
TGF-beta signaling pathway
INOH website
PDGF signaling pathway pathway
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
cd40_pathway
CD40/CD40L signaling
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
lysophospholipid_pathway
LPA receptor mediated events
rb_1pathway
Regulation of retinoblastoma protein
il2_1pathway
IL2-mediated signaling events
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ps1pathway
Presenilin action in Notch and Wnt signaling
il1pathway
IL1-mediated signaling events
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
s1p_s1p2_pathway
S1P2 pathway
p53downstreampathway
Direct p53 effectors
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
erbb1_downstream_pathway
ErbB1 downstream signaling
atf2_pathway
ATF-2 transcription factor network
fak_pathway
Signaling events mediated by focal adhesion kinase
il12_stat4pathway
IL12 signaling mediated by STAT4
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ilk_pathway
Integrin-linked kinase signaling
ap1_pathway
AP-1 transcription factor network
reg_gr_pathway
Glucocorticoid receptor regulatory network
rac1_pathway
RAC1 signaling pathway
fgf_pathway
FGF signaling pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
tcrjnkpathway
JNK signaling in the CD4+ TCR pathway
cdc42_pathway
CDC42 signaling events
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
ret_pathway
Signaling events regulated by Ret tyrosine kinase
rhoa_pathway
RhoA signaling pathway
ar_tf_pathway
Regulation of Androgen receptor activity
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
hnf3apathway
FOXA1 transcription factor network
pdgfrapathway
PDGFR-alpha signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
telomerasepathway
Regulation of Telomerase
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt P05412
TrEMBL
UniProt Splice Variant
Entrez Gene 3725
UniGene Hs.525704 Hs.696684
RefSeq NM_002228
HUGO HGNC:6204
OMIM 165160
CCDS CCDS610
HPRD
IMGT
EMBL AL136985 AY217548 BC002646 BC006175 BC009874 BC068522 BT019759 J04111
GenPept AAA59197 AAH06175 AAH09874 AAH68522 AAO22993 AAV38564 CAC10201
RNA Seq Atlas 3725

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca