InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHD3

Summary

InnateDB Gene

IDBG-27053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHD3

Gene Name

chromodomain helicase DNA binding protein 3

Synonyms

Mi-2a; Mi2-ALPHA; ZFH

Species

Homo sapiens

Ensembl Gene

ENSG00000170004

Encoded Proteins

IDBP-27055

chromodomain helicase DNA binding protein 3

IDBP-27057

chromodomain helicase DNA binding protein 3

IDBP-27059

chromodomain helicase DNA binding protein 3

IDBP-366897

chromodomain helicase DNA binding protein 3

IDBP-366901

chromodomain helicase DNA binding protein 3

IDBP-366902

chromodomain helicase DNA binding protein 3

IDBP-760124

IDBP-763191

IDBP-758625

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7884806-7912760

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000380358	ENSP00000369716
ENST00000330494	ENSP00000332628
ENST00000358181	ENSP00000350907
ENST00000452447	ENSP00000405861
ENST00000439235	ENSP00000395252
ENST00000449744	ENSP00000411959
ENST00000479080
ENST00000470531	ENSP00000467547
ENST00000466233
ENST00000473376
ENST00000481999
ENST00000573936	ENSP00000459321
ENST00000574022
ENST00000572750
ENST00000571249	ENSP00000458861
ENST00000570758
ENST00000572579

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 190 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	190 [view]
Protein-Protein	189 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006325	chromatin organization
GO:0006333	chromatin assembly or disassembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007051	spindle organization
GO:0008152	metabolic process
GO:0016568	chromatin modification
GO:0032508	DNA duplex unwinding
GO:0051297	centrosome organization