InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AP2A1

Summary

InnateDB Gene

IDBG-63459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP2A1

Gene Name

adaptor-related protein complex 2, alpha 1 subunit

Synonyms

ADTAA; AP2-ALPHA; CLAPA1

Species

Homo sapiens

Ensembl Gene

ENSG00000196961

Encoded Proteins

IDBP-63461

adaptor-related protein complex 2, alpha 1 subunit

IDBP-63463

adaptor-related protein complex 2, alpha 1 subunit

IDBP-764819

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49766968-49807113

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000359032	ENSP00000351926
ENST00000354293	ENSP00000346246
ENST00000601356
ENST00000600199
ENST00000593788
ENST00000594838
ENST00000597774	ENSP00000472492
ENST00000600466

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	66 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008565	protein transporter activity
GO:0019901	protein kinase binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006895	Golgi to endosome transport
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0015031	protein transport
GO:0016032	viral process
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050690	regulation of defense response to virus by virus
GO:1900126	negative regulation of hyaluronan biosynthetic process

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0030117	membrane coat
GO:0030122	AP-2 adaptor complex
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030131	clathrin adaptor complex
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0043234	protein complex