Homo sapiens Gene: CAPN9
Summary
InnateDB Gene IDBG-107366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPN9
Gene Name calpain 9
Synonyms GC36; nCL-4
Species Homo sapiens
Ensembl Gene ENSG00000135773
Encoded Proteins
calpain 9
calpain 9
calpain 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:230747384-230802003
Strand Forward strand
Band q42.2
Transcripts
ENST00000271971 ENSP00000271971
ENST00000366666 ENSP00000355626
ENST00000354537 ENSP00000346538
ENST00000480004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498021
RefSeq NM_006615 NM_016452 XM_005273010
HUGO
OMIM
CCDS CCDS1586 CCDS31053
HPRD 05909
IMGT
EMBL
GenPept
RNA Seq Atlas