Version 5.4
Homo sapiens Gene: SEPSECS
Summary
InnateDB Gene IDBG-12103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPSECS
Gene Name Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109618
Encoded Proteins
IDBP-12105
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-12107
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-476423
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-483961
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
IDBP-474813
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:25120014-25160442
Strand Reverse strand
Band p15.2
Transcripts
ENST00000382103 ENSP00000371535
ENST00000358971 ENSP00000351857
ENST00000514585 ENSP00000421880
ENST00000503150 ENSP00000423850
ENST00000515272
ENST00000505513
ENST00000513285 ENSP00000423361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016785 transferase activity, transferring selenium-containing groups
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0008152 metabolic process
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029173
View Gene Order
ENSBTAG00000014616
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00450
Selenocompound metabolism pathway
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9HD40
TrEMBL
UniProt Splice Variant
Entrez Gene 51091
UniGene Hs.253305
RefSeq NM_016955 XM_005248168 XM_006713965
HUGO HGNC:30605
OMIM 613009
CCDS CCDS3432
HPRD 11561
IMGT
EMBL AC007073 AC104662 AF146396 AF282065 AJ238617 AJ277541 AK292476 BC023539 BC117202 BX648976 CH471069
GenPept AAD33963 AAG00491 AAH23539 AAI17203 BAF85165 CAB62209 CAB89517 EAW92832
RNA Seq Atlas 51091

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca