Version 5.4
Mus musculus Gene: Steap4
Summary
InnateDB Gene IDBG-133094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Steap4
Gene Name STEAP family member 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000012428
Encoded Proteins
IDBP-249686
STEAP family member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127954:
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:7960472-7982213
Strand Forward strand
Band A1
Transcripts
ENSMUST00000115421 ENSMUSP00000111081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008823 cupric reductase activity
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Biological Process
GO:0015677 copper ion import
GO:0045444 fat cell differentiation
GO:0055072 iron ion homeostasis
GO:0055114 oxidation-reduction process
GO:0097461 ferric iron import into cell
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127954
View Gene Order
ENSBTAG00000002340
Not yet available
Cross-References
SwissProt Q923B6
TrEMBL
UniProt Splice Variant
Entrez Gene 117167
UniGene Mm.31403 Mm.472212
RefSeq NM_054098
OMIM
CCDS CCDS39008
HPRD
IMGT
MGI ID MGI:1923560
MGI Symbol Steap4
EMBL AJ319746 AK040760 AY029778 BC006651
GenPept AAH06651 AAK40270 BAC30696 CAC41351
RNA Seq Atlas 117167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca