Version 5.4
| Mus musculus Gene: Upf3a | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-135947.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Upf3a | ||||||
| Gene Name | UPF3 regulator of nonsense transcripts homolog A (yeast) | ||||||
| Synonyms | 2600001C03Rik; 4930546M19Rik; RENT3A; UPF3 | ||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000038398 | ||||||
| Encoded Proteins |
UPF3 regulator of nonsense transcripts homolog A (yeast)
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169062:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 8:13785615-13798538 | ||||||
| Strand | Forward strand | ||||||
| Band | A1.1 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME | |||||||
| KEGG |
RNA transport pathway
mRNA surveillance pathway pathway
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| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Nonsense-Mediated Decay (NMD) pathway
Gene Expression pathway
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| KEGG |
RNA transport pathway
mRNA surveillance pathway pathway
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| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | Q3ULJ3 Q9CTQ4 Q9CUH6 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 67031 | ||||||
| UniGene | Mm.44858 | ||||||
| RefSeq | NM_025924 | ||||||
| OMIM | |||||||
| CCDS | CCDS40235 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:1914281 | ||||||
| MGI Symbol | Upf3a | ||||||
| EMBL | AC134623 AC139186 AK016053 AK020823 AK145471 BC116988 BC119035 CH466566 | ||||||
| GenPept | AAI16989 AAI19036 BAB30093 BAB32218 BAE26455 EDL22167 | ||||||
| RNA Seq Atlas | 67031 | ||||||