InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppm1f

Summary

InnateDB Gene

IDBG-137609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppm1f

Gene Name

protein phosphatase 1F (PP2C domain containing)

Synonyms

1110021B16Rik; 4933427B07Rik; CaMKPase; mKIAA0015; Popx2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026181

Encoded Proteins

IDBP-137611

protein phosphatase 1F (PP2C domain containing)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100034:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:16896469-16927364

Strand

Forward strand

Band

Transcripts

ENSMUST00000027373	ENSMUSP00000027373
ENSMUST00000145978

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016576	histone dephosphorylation
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035690	cellular response to drug
GO:0035970	peptidyl-threonine dephosphorylation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045927	positive regulation of growth
GO:0050921	positive regulation of chemotaxis
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100034

View Gene Order

ENSBTAG00000006938

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.230296

RefSeq

NM_176833 XM_006522507 XM_006522508

OMIM

CCDS

CCDS27991

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas