Version 5.4
Mus musculus Gene: Il6
Summary
InnateDB Gene IDBG-144970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il6
Gene Name interleukin 6
Synonyms Il-6
Species Mus musculus
Ensembl Gene ENSMUSG00000025746
Encoded Proteins
IDBP-144972
interleukin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21148800
Il6 trans-signaling via Stat3 is a critical modulator of LPS-driven pro-inflammatory responses through cross-talk regulation of the Tlr4/Mal signaling pathway as a broader mechanism that regulates the severity of the host inflammatory response.
PMID 22096605
Il6 synthesis is regulated by the opposing effects of prostaglandin (PG)E(2) and PGD(2) in human chondrocytes. Il6 synthesis is increased by PGE2 and decreased by PGD2 through the modulation of Tlr4 synthesis. (Demonstrated in human)
PMID 22030478
Activation of either Tlr4 or Tlr2/6 significantly increased Il6 expression by U937 mononuclear cells. Co-activation of Tlr4 and Tlr2/6, led to a further augmentation on Il6 expression. (Demonstrated in human)
PMID 22426116
Il6 is strategically upregulated by virulent Mycobacterium tuberculosis to inhibit the induction of innate immunity. (Demonstrated in human)
PMID 23359591
Mycobacterium tuberculosis regulates host IL6 production to inhibit type I interferon-signalling.
PMID 24412616
Il6 causes compromised tissue repair by shifting acute inflammation into a more chronic profibrotic state through induction of T helper type1 cell responses as a consequence of recurrent inflammation.
PMID 25398005
Ybx1 controls intracellular Il6 mRNA levels in a cell type-specific manner, leading to functions that are dependent on the extracellular and intracellular distribution of Ybx1.
PMID 25725105
Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.
PMID 25595775
Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
PMID 26287468
Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:30013161-30019968
Strand Forward strand
Band B1
Transcripts
ENSMUST00000026845 ENSMUSP00000026845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 10 [view]
Protein-DNA 31 [view]
Protein-RNA 1 [view]
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001781 neutrophil apoptotic process
GO:0002675 positive regulation of acute inflammatory response
GO:0006469 negative regulation of protein kinase activity
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007568 aging
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0009617 response to bacterium
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010996 response to auditory stimulus
GO:0014070 response to organic cyclic compound
GO:0016049 cell growth
GO:0019221 cytokine-mediated signaling pathway
GO:0031000 response to caffeine
GO:0031018 endocrine pancreas development
GO:0031175 neuron projection development
GO:0031667 response to nutrient levels
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032868 response to insulin
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043200 response to amino acid
GO:0043410 positive regulation of MAPK cascade
GO:0045079 negative regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045454 cell redox homeostasis
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045727 positive regulation of translation
GO:0045740 positive regulation of DNA replication
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046677 response to antibiotic
GO:0046716 muscle cell cellular homeostasis
GO:0046849 bone remodeling
GO:0046888 negative regulation of hormone secretion
GO:0048635 negative regulation of muscle organ development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050710 negative regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0051602 response to electrical stimulus
GO:0051607 defense response to virus
GO:0051897 positive regulation of protein kinase B signaling
GO:0051971 positive regulation of transmission of nerve impulse
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091 glucagon secretion
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071549 cellular response to dexamethasone stimulus
GO:0072540 T-helper 17 cell lineage commitment
GO:1901215 negative regulation of neuron death
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005896 interleukin-6 receptor complex
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_189085
Disease pathway
REACT_252337
SHC-related events pathway
REACT_242240
RAF/MAP kinase cascade pathway
REACT_254215
Signaling by GPCR pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_261365
Interleukin-2 signaling pathway
REACT_188957
Cellular responses to stress pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_227951
Signaling by VEGF pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_188574
SHC1 events in ERBB2 signaling pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_245086
VEGFR2 mediated cell proliferation pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_239466
SHC-mediated signalling pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_257981
ERK activation pathway
REACT_247448
ERK1 activation pathway
REACT_188580
SHC1 events in ERBB4 signaling pathway
REACT_188820
Cellular Senescence pathway
REACT_239722
Signalling to RAS pathway
REACT_260286
SHC1 events in EGFR signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_262560
Frs2-mediated activation pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_231290
Signalling to ERKs pathway
REACT_261687
Signaling by Interleukins pathway
REACT_199118
Interleukin-6 signaling pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_248921
Signalling by NGF pathway
REACT_263353
Signaling by PDGF pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_188576
Developmental Biology pathway
REACT_241824
SOS-mediated signalling pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_263321
ERK2 activation pathway
REACT_234035
ARMS-mediated activation pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_188528
GRB2 events in ERBB2 signaling pathway
REACT_188529
Signaling by Leptin pathway
REACT_250933
Prolonged ERK activation events pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_242456
Signaling by FGFR pathway
REACT_245103
GRB2 events in EGFR signaling pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_188530
FCERI mediated MAPK activation pathway
REACT_188220
SHC-related events triggered by IGF1R pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_252757
Signalling to p38 via RIT and RIN pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu05332
Graft-versus-host disease pathway
mmu05020
Prion diseases pathway
mmu05200
Pathways in cancer pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu04621
NOD-like receptor signaling pathway pathway
mmu04623
Cytosolic DNA-sensing pathway pathway
mmu05146
Amoebiasis pathway
mmu05144
Malaria pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
mmu05143
African trypanosomiasis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-6 signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P08505
TrEMBL A2RTD1
UniProt Splice Variant
Entrez Gene 16193
UniGene
RefSeq NM_031168
OMIM
CCDS CCDS19153
HPRD
IMGT
MGI ID MGI:96559
MGI Symbol Il6
EMBL AK150440 BC132458 BC138766 CH466524 J03783 M20572 M24221 X06203 X51457 X54542
GenPept AAA39301 AAA39302 AAA68814 AAI32459 AAI38767 BAE29562 CAA29560 CAA35824 CAA38411 EDL37258
RNA Seq Atlas 16193

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca