Version 5.4
Mus musculus Gene: Col15a1
Summary
InnateDB Gene IDBG-145937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col15a1
Gene Name collagen, type XV, alpha 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028339
Encoded Proteins
IDBP-145939
collagen, type XV, alpha 1
IDBP-145943
collagen, type XV, alpha 1
IDBP-266028
collagen, type XV, alpha 1
IDBP-266030
collagen, type XV, alpha 1
IDBP-534182
collagen, type XV, alpha 1
IDBP-533545
collagen, type XV, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204291:
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, Jul 2008]
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:47208161-47313167
Strand Forward strand
Band B1
Transcripts
ENSMUST00000102917 ENSMUSP00000099981
ENSMUST00000082303 ENSMUSP00000080921
ENSMUST00000107731 ENSMUSP00000103359
ENSMUST00000107730 ENSMUSP00000103358
ENSMUST00000124105
ENSMUST00000148103
ENSMUST00000140094
ENSMUST00000140413 ENSMUSP00000119292
ENSMUST00000146967 ENSMUSP00000118637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0005581 collagen trimer
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204291
View Gene Order
ENSBTAG00000010082
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04974
Protein digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_120729
Collagen formation pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL A2AJY6
UniProt Splice Variant
Entrez Gene 12819
UniGene Mm.233547
RefSeq NM_009928 XM_006537600 XM_006537601
OMIM
CCDS CCDS18159
HPRD
IMGT
MGI ID MGI:88449
MGI Symbol Col15a1
EMBL AL772232 AL928652
GenPept
RNA Seq Atlas 12819

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca