InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gpr77

Summary

InnateDB Gene

IDBG-146283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr77

Gene Name

G protein-coupled receptor 77

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074361

Encoded Proteins

IDBP-146285

G protein-coupled receptor 77

IDBP-622450

G protein-coupled receptor 77

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21630250

Gpr77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of Gpr77 results in the amplification of complement pro-inflammatory responses.

InnateDB Annotation from Orthologs

Summary

PMID 21630250

[Homo sapiens] GPR77 is an alternate receptor for C5a and is negatively regulated by the TLR-signalling pathway. TLR-mediated inhibition of GPR77 results in the amplification of complement pro-inflammatory responses. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134830:
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:16234585-16244154

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098792	ENSMUSP00000096389
ENSMUST00000171425	ENSMUSP00000133056

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004944	C5a anaphylatoxin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032720	negative regulation of tumor necrosis factor production
GO:0045087	innate immune response (InnateDB)
GO:0050679	positive regulation of epithelial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090024	negative regulation of neutrophil chemotaxis
GO:1900165	negative regulation of interleukin-6 secretion
GO:2000482	regulation of interleukin-8 secretion