Version 5.4
Homo sapiens Gene: TNFRSF19
Summary
InnateDB Gene IDBG-15073.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF19
Gene Name tumor necrosis factor receptor superfamily, member 19
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127863
Encoded Proteins
IDBP-15075
tumor necrosis factor receptor superfamily, member 19
IDBP-15081
tumor necrosis factor receptor superfamily, member 19
IDBP-15083
tumor necrosis factor receptor superfamily, member 19
IDBP-292477
tumor necrosis factor receptor superfamily, member 19
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:23570370-23676104
Strand Forward strand
Band q12.12
Transcripts
ENST00000248484 ENSP00000248484
ENST00000382263 ENSP00000371698
ENST00000382258 ENSP00000371693
ENST00000403372 ENSP00000385408
ENST00000464735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
Biological Process
GO:0001942 hair follicle development
GO:0006915 apoptotic process
GO:0007254 JNK cascade
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060548
View Gene Order
ENSBTAG00000018300
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q9NS68
TrEMBL A0A024RDM5
UniProt Splice Variant
Entrez Gene 55504
UniGene Hs.149168 Hs.730848
RefSeq NM_001204458 NM_001204459 NM_018647 NM_148957 XM_005266445
HUGO HGNC:11915
OMIM 606122
CCDS CCDS55893 CCDS9301 CCDS9302
HPRD
IMGT
EMBL AB040434 AF167555 AF246998 AF246999 AK292874 AK292891 AK304290 AL161422 AL354815 AY358888 BC047321 CH471075
GenPept AAF71828 AAH47321 AAK28395 AAK28396 AAQ89247 BAB03269 BAF85563 BAF85580 BAG65148 CAH70837 CAH70838 EAX08326 EAX08327
RNA Seq Atlas 55504

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca