Version 5.4
Mus musculus Gene: Cd86
Summary
InnateDB Gene IDBG-158071.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd86
Gene Name CD86 antigen
Synonyms B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1; Ly-58; Ly58; MB7; MB7-2; TS/A-2
Species Mus musculus
Ensembl Gene ENSMUSG00000022901
Encoded Proteins
IDBP-158075
CD86 antigen
IDBP-540651
CD86 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25549946
Tmem126a upregulates genes involved in antigen presentation; such as Icam1, MHC II, Cd86 and Cd40, via the Tlr4 signal transduction pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114013:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:36603869-36666081
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000089620 ENSMUSP00000087047
ENSMUST00000154485
ENSMUST00000135280 ENSMUSP00000117756
ENSMUST00000145506
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 1 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0001878 response to yeast
GO:0002224 toll-like receptor signaling pathway
GO:0002309 T cell proliferation involved in immune response
GO:0002668 negative regulation of T cell anergy
GO:0007568 aging
GO:0032496 response to lipopolysaccharide
GO:0034341 response to interferon-gamma
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042113 B cell activation
GO:0042493 response to drug
GO:0043011 myeloid dendritic cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071248 cellular response to metal ion
GO:0071345 cellular response to cytokine stimulus
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000114013
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_226151
CD28 dependent PI3K/Akt signaling pathway
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_261451
CD28 dependent Vav1 pathway pathway
REACT_204081
CD28 co-stimulation pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_261568
CTLA4 inhibitory signaling pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04940
Type I diabetes mellitus pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu05330
Allograft rejection pathway
mmu05332
Graft-versus-host disease pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05320
Autoimmune thyroid disease pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu05416
Viral myocarditis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19358
CD28 dependent PI3K/Akt signaling pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04940
Type I diabetes mellitus pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05332
Graft-versus-host disease pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL D3Z363
UniProt Splice Variant
Entrez Gene 12524
UniGene
RefSeq NM_019388 XM_006521741 XM_006521742
OMIM
CCDS CCDS28155
HPRD
IMGT
MGI ID MGI:101773
MGI Symbol Cd86
EMBL AC117662
GenPept
RNA Seq Atlas 12524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca