InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hc

Summary

InnateDB Gene

IDBG-163835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

hemolytic complement

Synonyms

C5; C5a; He

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026874

Encoded Proteins

IDBP-163839

hemolytic complement

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25725105

Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.

InnateDB Annotation from Orthologs

Summary

PMID 18039528

[Homo sapiens] C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains, C5a is a complement anaphylatoxin that can stimulate the generation of nitric oxide along with the secretion of histamine and leukotriene LTC4 from several cell types and can bring about an increase in vascular permeability that facilitates eosinophil accumulation at sites of allergic inflammation.

PMID 10441679

[Homo sapiens] C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains. C5b first associates with complement component 6 (C6), which in turn initiates the assembly of the cytolytic membrane attack complex (MAC).

PMID 21063021

[Homo sapiens] C5 fragments are released from neutrophils upon their activation of the alternative complement pathway and this further amplifies neutrophil pro-inflammatory responses.

PMID 25539819

[Homo sapiens] C5 (C5a) is a critical mediator in blood during Candida albicans infection.

PMID 26176669

[Homo sapiens] Staphylococcus aureus-induced neutrophil dysfunction correlates with the loss of C5AR1 from the neutrophil cell surface and results in C5a (C5)-induced CEACAM8 overexpression.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106804:
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:34983331-35061438

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028233	ENSMUSP00000028233
ENSMUST00000156412
ENSMUST00000156049
ENSMUST00000125549
ENSMUST00000151628

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004866	endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0031714	C5a anaphylatoxin chemotactic receptor binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002523	leukocyte migration involved in inflammatory response
GO:0006874	cellular calcium ion homeostasis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006957	complement activation, alternative pathway
GO:0006958	complement activation, classical pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010700	negative regulation of norepinephrine secretion
GO:0010760	negative regulation of macrophage chemotaxis
GO:0010951	negative regulation of endopeptidase activity
GO:0019835	cytolysis
GO:0033602	negative regulation of dopamine secretion
GO:0042593	glucose homeostasis
GO:0045087	innate immune response (InnateDB)
GO:0045766	positive regulation of angiogenesis
GO:0050921	positive regulation of chemotaxis
GO:0090197	positive regulation of chemokine secretion