Version 5.4
| Mus musculus Gene: Trat1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-164471.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Trat1 | ||||||||||
| Gene Name | T cell receptor associated transmembrane adaptor 1 | ||||||||||
| Synonyms | C030046M14Rik; Tcrim; Trim | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000030775 | ||||||||||
| Encoded Proteins |
T cell receptor associated transmembrane adaptor 1
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] TRAT1 (TRIM56) is an interferon-inducible E3 ubiquitin ligase that modulates TMEM173 (STING) to confer double-stranded DNA-mediated innate immune responses.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163519:
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 16:48734690-48771956 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | B5 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
Downstream TCR signaling pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
TCR signaling pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH |
TCR pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Downstream TCR signaling pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
TCR signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | Mm.167298 | ||||||||||
| RefSeq | NM_198297 XM_006522730 XM_006522731 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS37352 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | |||||||||||
| MGI Symbol | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||