Version 5.4
Mus musculus Gene: Cib2
Summary
InnateDB Gene IDBG-166743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cib2
Gene Name calcium and integrin binding family member 2
Synonyms 2810434I23Rik; AI449053
Species Mus musculus
Ensembl Gene ENSMUSG00000037493
Encoded Proteins
IDBP-166745
calcium and integrin binding family member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136425:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:54544794-54560218
Strand Reverse strand
Band A5.3
Transcripts
ENSMUST00000041901 ENSMUSP00000038527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0045494 photoreceptor cell maintenance
GO:0055074 calcium ion homeostasis
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005927 muscle tendon junction
GO:0031594 neuromuscular junction
GO:0042383 sarcolemma
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136425
View Gene Order
ENSBTAG00000010981
Not yet available
Cross-References
SwissProt Q9Z309
TrEMBL Q544Z8
UniProt Splice Variant
Entrez Gene 56506
UniGene Mm.42192
RefSeq NM_019686
OMIM
CCDS CCDS40642
HPRD
IMGT
MGI ID MGI:1929293
MGI Symbol Cib2
EMBL AB016080 AK005347 AK013240 BC005739 CH466522
GenPept AAH05739 BAA36545 BAB23968 BAB28737 EDL25816
RNA Seq Atlas 56506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca