Homo sapiens Gene: CLEC4E
Summary
InnateDB Gene IDBG-17212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC4E
Gene Name C-type lectin domain family 4, member E
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166523
Encoded Proteins
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
C-type lectin domain family 4, member E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CLEC4E, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC4E is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.
Glycerol monomycolate is a unique ligand for CLEC4E (Mincle).
Cholesterol crystals are an endogenous ligand for CLEC4E and their binding activates innate immune responses.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Clec4e, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec4e is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.
[Mus musculus] The expression of Clec4e (Mincle) and its downstream signal phospho-Syk/Syk increases after cerebral ischemia and reperfusion.
[Mus musculus] Clec4d is an inducible myeloid-expressed C-type lectin receptor, whose expression is tightly linked to that of Clec4e.
Entrez Gene
Summary This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8533305-8540963
Strand Reverse strand
Band p13.31
Transcripts
ENST00000299663 ENSP00000299663
ENST00000446457 ENSP00000387737
ENST00000450725 ENSP00000404994
ENST00000446809
ENST00000545274 ENSP00000443034
ENST00000537698 ENSP00000443328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
GO:0050715 positive regulation of cytokine secretion
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL F8WFA1
UniProt Splice Variant
Entrez Gene 26253
UniGene Hs.236516
RefSeq NM_014358
HUGO HGNC:14555
OMIM 609962
CCDS CCDS8594
HPRD 13075
IMGT
EMBL AC092746
GenPept
RNA Seq Atlas 26253