InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lass2

Summary

InnateDB Gene

IDBG-172404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lass2

Gene Name

LAG1 homolog, ceramide synthase 2

Synonyms

0610013I17Rik; AI225939; Lass2; TRH3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015714

Encoded Proteins

IDBP-172406

LAG1 homolog, ceramide synthase 2

IDBP-535710

LAG1 homolog, ceramide synthase 2

IDBP-540354

LAG1 homolog, ceramide synthase 2

IDBP-532533

LAG1 homolog, ceramide synthase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143418:
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:95314791-95323599

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000015858	ENSMUSP00000015858
ENSMUST00000129267	ENSMUSP00000121110
ENSMUST00000133748
ENSMUST00000154055
ENSMUST00000156850
ENSMUST00000139498	ENSMUSP00000122672
ENSMUST00000139866	ENSMUSP00000120190
ENSMUST00000134702
ENSMUST00000142398

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0030148	sphingolipid biosynthetic process
GO:0046513	ceramide biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane