InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Clock

Summary

InnateDB Gene

IDBG-172856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clock

Gene Name

circadian locomotor output cycles kaput

Synonyms

5330400M04Rik; bHLHe8; KAT13D; mKIAA0334

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029238

Encoded Proteins

IDBP-172860

circadian locomotor output cycles kaput

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with Arntl (Bmal1) that binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Polymorphisms in this gene may be associated with behavioral changes, obesity, and metabolic syndrome. Two transcripts encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:76212177-76304548

Strand

Reverse strand

Band

C3.3

Transcripts

ENSMUST00000075159

ENSMUSP00000074656

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	47 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0016573	histone acetylation
GO:0032922	circadian regulation of gene expression
GO:0042634	regulation of hair cycle
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050796	regulation of insulin secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051775	response to redox state
GO:0071479	cellular response to ionizing radiation
GO:2000074	regulation of type B pancreatic cell development
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0033391	chromatoid body
GO:0043231	intracellular membrane-bounded organelle