InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tlr7

Summary

InnateDB Gene

IDBG-185532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlr7

Gene Name

toll-like receptor 7

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044583

Encoded Proteins

IDBP-185534

toll-like receptor 7

IDBP-256583

toll-like receptor 7

IDBP-256585

toll-like receptor 7

IDBP-532345

toll-like receptor 7

IDBP-538932

toll-like receptor 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17452530

Tlr7, 9, and 3 interact with the endoplasmic reticulum (ER) membrane protein UNC93B and this is essential for proper TLR signaling.

PMID 21037581

Tlr7 is expressed in C-fiber primary sensory neurons and is important for inducing itch (pruritus), but is not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain in mice

PMID 21282509

Tlr7 signaling pathway plays a pivotal role in fungal pathogen recognition and is essential for the subsequent Ifnb signaling.

PMID 21402738

Tlr7 requires proteolytic processing in endolysosome by asparagine endopeptidase and cathepsin in the endolysosome to initiate signalling.

PMID 21487111

Tlr7 agonist, such as imidazoquinolines, accumulate in the MHC class II loading compartment - this pH-dependent localization is required for the activation of plasmacytoid dendritic cells. (Demonstrated in human)

PMID 21730058

TLR7 inflammatory signalling leads to cardiac fibrosis in autoimmune associated congenital heart block.. (Demonstrated in human)

PMID 21734241

Tlr7 and Tlr8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to Tlr7/8 agonists and this may play a role in systemic autoimmunity.

PMID 21998589

Tlr7 is responsible for the detection of retroviruses and serves as a key checkpoint controlling the development of germinal center B cells.

PMID 22396599

Tlr7 signalling induces autophagy in HIV-infected plasmacytoid dendritic cells; this process is necessary for the induction of IFN-alpha. (Demonstrated in mice)

PMID 22753494

Tlr7 binds to exosomal Mir21 and Mir29a secreted by tumour cells and initiates a prometastatic inflammatory response.

PMID 22952664

Aberrant TLR7 activation induces Epstein-Barr viral protein LMP1 expression, which exacerbates IFN production in lupus patients. (Demonstrated in human)

PMID 23142781

Tlr7 contributes to the control of activated endogenous retroviruses (ERVs) and ERV-induced tumours.

PMID 24270517

Mir126-Kdr axis is an important regulator of the innate response. Mir126 controls the survival and function of plasmacytoid dendritic cells and regulates gene expression of Tlr7, Tlr9, Nfkb1 and Kdr.

PMID 25848864

Treml4 is an essential positive regulator of Tlr7 signalling. Treml4(-/-) macrophages are hyporesponsive to Tlr7 agonists and fail to produce type I interferons due to impaired phosphorylation of Stat1 by Mapk14 and decreased recruitment of Myd88 to Tlr7.

PMID 25917529

Neuronal Tlr7 recognizes endogenous ligands such as the miRNAs Let7c and miR21 and plays a negative role in controlling neuronal growth in a cell-autonomous manner.

PMID 26363072

Extracellular RNA of cardiac origin exhibits a potent pro-inflammatory property in vitro and in vivo and induces cytokine production through Tlr7-Myd88 signalling.

InnateDB Annotation from Orthologs

Summary

PMID 18071655

[Homo sapiens] TLR7 recognizes long single-stranded RNA and short double-stranded RNA.

PMID 15034168

[Homo sapiens] TLR7 recognizes the single-stranded RNA viruses, vesicular stomatitis virus and influenza virus, resulting in activation of co-stimulatory molecules and production of cytokines.

PMID 14976261

[Homo sapiens] TLR7-dependent production of inflammatory cytokines can be induced by single-stranded RNA (ssRNA) molecules of non-viral origin.

PMID 14579267

[Homo sapiens] TLR7, 8 and 9 form a functional subgroup within the TLR family that recognizes pathogen-associated molecular patterns in endosomal/lysosomal compartments.

PMID 20034855

[Homo sapiens] TLR7/9-mediated innate immune responses via selected TLR pathways can be negatively regulated by a human microsatellite DNA-mimicking oligodeoxynucleotide with CCT repeats.

PMID 20007807

[Homo sapiens] TLR7-dependent innate immune response is induced by free human T-cell leukemia virus 1 (HTLV-1) in killer plasmacytoid dendritic cells, resulting in high production of IFN-alpha and TRAIL relocalization.

PMID 21037581

[Homo sapiens] TLR7 is expressed in C-fiber primary sensory neurons and is important for inducing itch (pruritus), but is not necessary for eliciting mechanical, thermal, inflammatory and neuropathic pain. (Demonstrated in murine model)

PMID 21282509

[Homo sapiens] TLR7 signalling pathway plays a pivotal role in fungal pathogen recognition and is essential for the subsequent IFNB signalling. (Demonstrated in murine model)

PMID 21402738

[Homo sapiens] TLR7 requires proteolytic processing in endolysosome by asparagine endopeptidase and cathepsin in the endolysosome to initiate signalling. (Demonstrated in murine model)

PMID 21487111

[Homo sapiens] TLR7 agonists, such as imidazoquinolines, accumulate in the MHC class II loading compartment - this pH-dependent localization is required for the activation of plasmacytoid dendritic cells.

PMID 21730058

[Homo sapiens] TLR7 inflammatory signalling leads to cardiac fibrosis in autoimmune associated congenital heart block.

PMID 21734241

[Homo sapiens] TLR7 and TLR8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to TLR7/8 agonists and this may play a role in systemic autoimmunity.

PMID 21998589

[Homo sapiens] TLR7 is responsible for the detection of retroviruses and serves as a key checkpoint controlling the development of germinal center B cells. (Demonstrated in mice)

PMID 22396599

[Homo sapiens] TLR7 signalling induces autophagy in HIV-infected plasmacytoid dendritic cells; this process is necessary for the induction of IFN-alpha.

PMID 22952664

[Homo sapiens] Aberrant TLR7 activation induces Epstein-Barr viral protein LMP1 expression, which exacerbates IFN production in lupus patients.

PMID 26130701

[Homo sapiens] IFN-λ1 is able to augment TLR-mediated B cell activation, partially attributed to an upregulation of TLR7 expression

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196664:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:167304929-167330558

Strand

Reverse strand

Band

Transcripts

ENSMUST00000060719	ENSMUSP00000061853
ENSMUST00000112164	ENSMUSP00000107789
ENSMUST00000112161	ENSMUSP00000107787
ENSMUST00000145284	ENSMUSP00000114305
ENSMUST00000137492	ENSMUSP00000120922
ENSMUST00000149507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0035197	siRNA binding

Biological Process

GO:0001774	microglial cell activation
GO:0002224	toll-like receptor signaling pathway
GO:0002282	microglial cell activation involved in immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007252	I-kappaB phosphorylation
GO:0032722	positive regulation of chemokine production
GO:0032755	positive regulation of interleukin-6 production
GO:0032757	positive regulation of interleukin-8 production
GO:0034154	toll-like receptor 7 signaling pathway
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045356	positive regulation of interferon-alpha biosynthetic process
GO:0045359	positive regulation of interferon-beta biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0051607	defense response to virus
GO:0052033	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0032009	early phagosome
GO:0043235	receptor complex